Mouse Startle Response Testing System

GBR-ABR
Non-invasive, kev tshawb fawb thiab kev siv tshuaj kho mob, plaub channel

Mouse Startle Response Testing System yog ib qho kev sim ntsuas cov cuab yeej tshwj xeeb tsim los txheeb xyuas qhov kev ntshai thiab kev ntxhov siab ntawm cov nas. Nws yog ua raws li cov qauv kev ntsuas tus cwj pwm zoo. Los ntawm kev nthuav tawm cov stimuli tshwj xeeb xws li suab lossis lub teeb rau cov nas thiab ua tib zoo saib thiab sau lawv cov lus teb raws li qhov kev xav, nws tuaj yeem ntsuas qhov kev ntshai thiab kev ntxhov siab ntawm cov nas. Cov txheej txheem no zoo li qhib lub qhov rais rau lub ntiaj teb sab hauv lub siab ntawm nas, ua rau cov kws tshawb fawb tau txais kev nkag siab tob rau hauv cov txheej txheem neuropsychological teb ntawm cov nas thaum ntsib cov stimuli sab nraud.

Routine Auditory Stimulation Startle Experiment: Lub kaw lus tuaj yeem ruaj khov thiab raug tso tawm suab stimuli ntawm ntau yam kev siv zog thiab ntau zaus, kom ntseeg tau qhov raug ntes ntawm cov cim tseem ceeb xws li amplitude thiab latency ntawm startle reflex ntawm nas nyob rau hauv cov lus teb rau lub suab nyob rau hauv niaj hnub auditory stimulation startle thwmsim. . Txawm hais tias nws tab tom tshawb nrhiav qhov yooj yim neural circuits ntawm tus nas auditory system thiab startle reflex lossis ntsuas qhov cuam tshuam ntawm cov tshuaj sib txawv lossis kev sim kev kho mob ntawm tus nas auditory startle teb, qhov kev sim ntsuas no tuaj yeem muab kev txhawb nqa cov ntaub ntawv txhim khu kev qha, tso lub hauv paus ruaj khov rau auditory- ntsig txog kev tshawb fawb neuroscience. Auditory Stimulation Habituation Study (Habituation): Thaum lub sij hawm kev tshawb fawb mus sij hawm ntev, lub kaw lus muaj peev xwm rov hais dua auditory stimuli thiab piav qhia meej txog cov kev hloov pauv hauv cov lus teb ntawm cov nas thaum cov stimuli nce. Qhov no yog qhov tsis muaj txiaj ntsig rau kev nkag siab tob txog lub luag haujlwm ntawm kev kawm thiab lub cim xeeb ntawm cov nas nyob rau hauv cov txheej txheem ntawm kev hnov ​​​​lus. Los ntawm kev kawm yuav ua li cas nas maj mam hloov mus rau rov hais dua auditory stimuli, cov kws tshawb fawb tuaj yeem nthuav tawm cov kev hloov pauv ntawm neural plasticity hauv lub hlwb thaum lub sij hawm kev nkag siab ntawm cov txheej txheem, muab cov ntaub ntawv pov thawj nplua nuj rau kev tshawb fawb theoretical hauv thaj chaw ntawm neuroscience. Prepulse Inhibition Test (PPI): Prepulse inhibition yog ib qho tseem ceeb tshwm sim ntawm sensorimotor gating thiab yog ze rau cov txheej txheem pathophysiological ntawm ntau yam kab mob hlwb. Peb qhov kev sim ntsuas muaj peev xwm tswj tau qhov tsis xws li lub sijhawm ncua sijhawm thiab qhov sib piv ntawm qhov kev txhawb nqa prepulse thiab lub zog pib, yog li ntsuas ntsuas qhov muaj peev xwm ua ntej ntawm cov nas. Qhov kev ua haujlwm no tshwj xeeb yog qhov tseem ceeb hauv kev tshawb fawb ntawm cov qauv kev puas siab puas ntsws. Piv txwv li, nyob rau hauv nas qauv ntawm schizophrenia, lub prepulse inhibition muaj peev xwm yog feem ntau ho impaired. Los ntawm qhov kev txiav txim siab ntawm PPI los ntawm cov txheej txheem no, cov kws tshawb fawb tuaj yeem tshawb nrhiav cov kab mob ntawm kev puas siab puas ntsws xws li schizophrenia, tshuaj ntsuam cov tshuaj kho mob lossis kev cuam tshuam, thiab muab cov tswv yim tshiab thiab lub hom phiaj rau kev kho mob ntawm cov kab mob hlwb.

Professional Soundproof Chamber Design: Lub kaw lus tau nruab nrog 8 ua tib zoo tsim me me soundproof chambers. Txhua lub suab tsis muaj suab nrov tau txais cov ntaub ntawv pov thawj zoo tshaj plaws thiab cov thev naus laus zis ua kom zoo tshaj plaws, uas tuaj yeem tiv thaiv cov suab nrov sab nraud cuam tshuam thiab ua kom lub suab ruaj khov thiab sib xws ntawm qhov chaw sim. Nyob rau hauv lub soundproof chamber, tsis xws li qhov ntau zaus, theem kev siv, thiab suab propagation kev taw qhia ntawm lub suab stimulus yuav precisely tswj, muab ib tug heev controllable thiab standardized auditory stimulus ib puag ncig rau nas, yog li xyuas kom meej qhov tseeb thiab kev ntseeg siab ntawm kev sim cov ntaub ntawv.

Full Audio Output Capability: Nws muaj lub zog tag nrho lub suab tso tawm muaj nuj nqi thiab tuaj yeem npog lub suab txhawb kev tawm suab los ntawm ntau yam ntawm tus nas auditory system mus rau lub suab nrov nrov. Txawm hais tias nws yog simulating low-frequency ib puag ncig lub suab tom qab los yog xa cov high-frequency acoustic signals, lub kaw lus muaj peev xwm ua kom raug thiab ruaj khov tso zis, ua tau raws li qhov yuav tsum tau ntawm ntau yam kev sim tsim qauv rau ntau haiv neeg thiab tshwj xeeb ntawm lub suab stimuli. Qhov no ua rau cov kws tshawb fawb hloov pauv hloov cov suab tsim nyog raws li kev tshawb fawb sib txawv thiab cov qauv kev sim thiab tshawb nrhiav cov yam ntxwv ntawm cov lus teb ntawm cov nas nyob rau hauv cov suab sib txawv thiab cov txheej txheem neural hauv qab.

Kev tshawb fawb txog Cov Qauv Kab Mob Siab

Schizophrenia: Schizophrenia yog ib qho kev puas siab puas ntsws nyuaj, thiab nws cov kab mob cuam tshuam nrog kev sib cuam tshuam ntawm ntau yam xws li noob caj noob ces, neurotransmitter imbalance, thiab ib puag ncig yam. Peb Mouse Startle Response Testing System ua lub luag haujlwm tseem ceeb hauv kev tshawb fawb schizophrenia. Los ntawm kev sib txuas nrog ntau yam tsiaj cov qauv ntawm tus mob schizophrenia (xws li cov qauv caj ces, cov qauv tshuaj, thiab cov qauv ib puag ncig), nws tuaj yeem soj ntsuam qhov txawv txav ntawm cov qauv nas hauv cov lus teb tsis txaus ntseeg, qhov ntsuas qhov ntsuas, thiab lwm yam, thiab tshawb nrhiav qhov cuam tshuam txog cov txheej txheem neurobiological ntawm cov nas. tus kab mob, xws li txawv txav dopaminergic neurotransmission, tsis meej glutamatergic neurotransmission, thiab kev ua haujlwm tsis zoo ntawm cortico-striatal-thalamic-cortical circuit. Cov kev tshawb fawb no tsis tsuas yog pab kom nkag siab tob txog cov kab mob ntawm tus kab mob schizophrenia tab sis kuj tseem muab cov kev sim tseem ceeb thiab tshuaj ntsuam xyuas lub platform rau kev tshawb fawb thiab kev loj hlob ntawm cov tshuaj antipsychotic tshiab.

Lwm Cov Kab Mob Siab: Ntxiv nrog rau tus mob schizophrenia, cov kab ke no tseem muaj kev siv dav hauv kev tshawb fawb tsiaj cov qauv ntawm cov kab mob neurodegenerative xws li Huntington's disease, Parkinson's disease, Alzheimer's disease, thiab lwm yam ntau yam kab mob hlwb. Hauv cov qauv nas ntawm Huntington tus kab mob, qhov kev ntsuam xyuas pib tuaj yeem siv los soj ntsuam cov kev hloov pauv hauv kev sib koom ua ke ntawm lub cev muaj zog thiab lub siab lub ntsws thaum lub sij hawm tus kab mob, muab cov lus qhia rau kev kawm txog cov txheej txheem pathological thiab muaj peev xwm kho cov ntsiab lus ntawm tus kab mob; nyob rau hauv Parkinson tus kab mob qauv, nws pab qhia txog qhov cuam tshuam ntawm dopaminergic neuron poob ntawm kev xav thiab kev coj tus cwj pwm ntawm cov nas thiab pab txhim kho cov tswv yim kho mob rau Parkinson tus kab mob ntsig txog cov tsos mob ntawm lub hlwb; nyob rau hauv Alzheimer's tus qauv qauv, nws tuaj yeem siv los ntsuas kev sib raug zoo ntawm kev paub txog kev ua haujlwm poob qis thiab kev hloov pauv hauv kev ntxhov siab thiab kev ntshai ntawm kev xav, muab cov ntaub ntawv kev coj tus cwj pwm rau kev tshawb nrhiav kev kho mob rau Alzheimer's disease.

Peb Qhov Kev Ntsuas Kev Ntsuas Tus Nas Startle tau tshwm sim los ua ib qho cuab yeej tseem ceeb hauv kev tshawb fawb thoob ntiaj teb neuroscience thiab mob hlwb. Ua tsaug rau nws cov kev ua tau zoo tshaj plaws, kev siv ntau yam kev sim, thiab cov kab mob dav dav adaptability. Nws nthuav tawm cov txiaj ntsig zoo tshaj plaws thiab kev tshawb fawb muaj peev xwm, txawm hais tias nyob rau hauv kev tshawb fawb txog kev puas siab puas ntsws ntawm cov kws kho mob hlwb hauv cov koom haum tshawb fawb premier lossis hauv kev tshawb nrhiav cov tshuaj kho mob hlwb tshiab los ntawm cov chaw muag tshuaj. Peb zoo siab txais tos cov neeg koom tes tshawb fawb thiab cov kws tshaj lij thoob ntiaj teb kom tau txais kev sib cuag, thaum peb siv zog los ua tus thawj coj tshiab hauv kev tshawb fawb neuropsychiatric thiab tawm tsam cov teeb meem nyuaj no.

Tsis tas li ntawd, peb muab kev tshuaj xyuas tus cwj pwm rau ntau hom tsiaj xws li locusts, kab laum, tub ceev xwm dev, thiab yoov txiv hmab txiv ntoo. Cov txheej txheem no tuaj yeem ua raws li cov lus qhia kev tshawb fawb sib txawv, muab cov ntaub ntawv tus cwj pwm raug rau kev tshuaj xyuas. Cov yam ntxwv los ntawm kev ua haujlwm siab, ntau qhov kev xav, kev nkag siab, thiab kev siv ntau yam, lawv qiv kev txhawb zog rau txhua qhov kev tshawb fawb tshawb fawb.

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